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Wnt1tm1.1Mze
Targeted Allele Detail
Summary
Symbol: Wnt1tm1.1Mze
Name: wingless-type MMTV integration site family, member 1; targeted mutation 1.1, Mark Zervas
MGI ID: MGI:5495278
Synonyms: Wnt1fl, Wnt1flox
Gene: Wnt1  Location: Chr15:98687738-98691711 bp, + strand  Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
Alliance: Wnt1tm1.1Mze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194842
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-pgk-gb2-Neo-FRT-loxP cassette was inserted in intron 1 and a loxP site was inserted in intron 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:194842)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt1 Mutation:  30 strains or lines available
References
Original:  J:194842 Yang J, et al., Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory