Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cxcl12tm1.1Sjm
Name:	C-X-C motif chemokine ligand 12; targeted mutation 1.1, Sean J Morrison
MGI ID:	MGI:5486672
Synonyms:	Cxcl12fl
Gene:	Cxcl12  Location: Chr6:117145496-117158328 bp, + strand  Genetic Position: Chr6, 54.81 cM, cytoband F1
Alliance:	Cxcl12tm1.1Sjm page

Germline Transmission:	Earliest citation of germline transmission: J:194748
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted 5' of exon 2 and an Frt-Neo-Frt-loxP cassette was placed 3' of the same exon. The selection cassette was subsequently removed by crossing with mice expressing flp recombinase. Condition cre expression creates a frame shift mutation. (J:194748)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcl12 Mutation:	24 strains or lines available

Original:	J:194748 Ding L, et al., Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013 Mar 14;495(7440):231-5
All:	6 reference(s)