Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hltftm1.1Arte
Name:	helicase-like transcription factor; targeted mutation 1.1, TaconicArtemis
MGI ID:	MGI:5484565
Gene:	Hltf  Location: Chr3:20111975-20172654 bp, + strand  Genetic Position: Chr3, 6.15 cM
Alliance:	Hltftm1.1Arte page

Germline Transmission:	Earliest citation of germline transmission: J:193813
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site and F3 flanked puro cassette were inserted upstream of exon 11 and a loxP site was inserted downstream of exon 13 via homologous recombination. Recombinase mediated recombination removed the selection cassette and exons 11-13. Western blot analysis confirmed the absence of protein expression in the hippocampus of homozygous mice. (J:193813)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hltf Mutation:	47 strains or lines available

Original:	J:193813 Oh YS, et al., SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell. 2013 Feb 14;152(4):831-43
All:	1 reference(s)