Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Brunhilde Wirth
MGI ID:	MGI:5484555
Synonyms:	PLS3V5tg
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir page

Germline Transmission:	Earliest citation of germline transmission: J:193844
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human PLS3 (5358) Pls3  (MGI:104807)   Mutation details: The construct inserted into the locus contains a CAG promoter, floxed neo/STOP cassette, human PLS3 cDNA with a V5-tag, IRES and GFP gene. Cre-mediated recombination removed the neo/STOP cassette. (J:193844)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:193844 Ackermann B, et al., Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. Hum Mol Genet. 2013 Apr 1;22(7):1328-47
All:	5 reference(s)