Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Hsd11b2tm1Yko Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev MGI ID: MGI:2386169 Synonyms: 11Beta-HSD2- Gene: Hsd11b2  Location: Chr8:106245387-106250620 bp, + strand  Genetic Position: Chr8, 53.04 cM Alliance: Hsd11b2tm1Yko page

Hyperplasia and hypertrophy of the distal renal tubular epithelium in Hsd11b2tm1Yko/Hsd11b2tm1Yko mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:53391
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 5 were replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot analysis of total kidney RNA. (J:53391)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b2 Mutation:	19 strains or lines available

Original:	J:53391 Kotelevtsev Y, et al., Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest. 1999 Mar;103(5):683-9
All:	13 reference(s)