Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hrastm1Mok
Name:	Harvey rat sarcoma virus oncogene; targeted mutation 1, Moyota Katsuki
MGI ID:	MGI:2386128
Synonyms:	H-ras (-)
Gene:	Hras  Location: Chr7:140770839-140773938 bp, - strand  Genetic Position: Chr7, 86.48 cM
Alliance:	Hrastm1Mok page

Germline Transmission:	Earliest citation of germline transmission: J:62962
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exons encoding the first 160 amino acids of the gene were replaced with a neomycin resistance cassette via homologous recombination. Skin lysates from homozygous mutant animals contained no detectable protein product as determined by Western blot analysis. (J:62962)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 15 strains available      Cell Lines: 0 lines available
Carrying any Hras Mutation:	30 strains or lines available

Original:	J:62962 Ise K, et al., Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene. 2000 Jun 15;19(26):2951-6
All:	6 reference(s)