Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Cdkl5tm1.1Joez Name: cyclin dependent kinase like 5; targeted mutation 1.1, Zhaolan Zhou MGI ID: MGI:5475468 Gene: Cdkl5  Location: ChrX:159567304-159777677 bp, - strand  Genetic Position: ChrX, 73.95 cM Alliance: Cdkl5tm1.1Joez page

Hindlimb clasping in Cdkl5tm1.1Joez/Y mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:193172
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette and exon 6. Western blot analysis confirmed the absence of protein expression. (J:193172)

Generation of the Cdkl5tm1.1Joez allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkl5 Mutation:	19 strains or lines available

Original:	J:193172 Wang IT, et al., Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21516-21
All:	13 reference(s)