Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nhej1tm1.1Ics
Name:	non-homologous end joining factor 1; targeted mutation 1.1, Mouse Clinical Institute
MGI ID:	MGI:5475156
Synonyms:	Cernu-
Gene:	Nhej1  Location: Chr1:75006505-75101870 bp, - strand  Genetic Position: Chr1, 38.56 cM, cytoband C3
Alliance:	Nhej1tm1.1Ics page

Germline Transmission:	Earliest citation of germline transmission: J:194422
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 4. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neo cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:194422)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nhej1 Mutation:	14 strains or lines available

Original:	J:194422 Vera G, et al., Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol Cell Biol. 2013 Feb;33(4):701-11
All:	4 reference(s)