Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm1.1(cre/ERT2)Mgoe
Name:	orthodenticle homeobox 2; targeted mutation 1.1, Magdalena Goetz
MGI ID:	MGI:5473314
Synonyms:	Otx2CreER
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm1.1(cre/ERT2)Mgoe page

Germline Transmission:	Earliest citation of germline transmission: J:194049
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Otx2tm1.1(cre/ERT2)Mgoe expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Otx2 (MGI:97451)   Mutation details: A cassette consisting of the cre/ERT2 sequence followed by the Otx2 3' UTR with the polyadenylation signal (and floxed neo marker) replaced the entire coding sequence of Otx2 following homologous recombination in ES cells. Founder animals were bred to CMV-deleter mice to remove the neo. (J:194049)

Activity:	Tissue activity of this recombinase allele
Driver:	Otx2 (mouse) Summary of all recombinase alleles driven by Otx2. Alliance mouse Otx2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All:	2 reference(s)