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Targeted Allele Detail
Symbol: Nkx6-1tm1Jlr
Name: NK6 homeobox 1; targeted mutation 1, John L Rubenstein
MGI ID: MGI:2386119
Synonyms: Nkx6.1-
Gene: Nkx6-1  Location: Chr5:101659184-101664711 bp, - strand  Genetic Position: Chr5, 48.84 cM
The gross morphology of Nkx6-1tm1Jlr/Nkx6-1tm1.2Msan embryos at E18.5

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:65594
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 1 including the translation initiation codon was replaced with a PGK-neo cassette via homologous recombination. (J:65594)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx6-1 Mutation:  2 strains or lines available
Original:  J:65594 Sander M, et al., Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec;127(24):5533-40
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory