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Cdkn2atm3.1Nesh
Targeted Allele Detail
Summary
Symbol: Cdkn2atm3.1Nesh
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 3.1, Norman E Sharpless
MGI ID: MGI:5471230
Synonyms: p16LUC
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2atm3.1Nesh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193498
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon1alpha was replaced with a translation start site, firefly luciferase cDNA and FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. Western blot analysis confirmed the lack of p16INK4a isoform expression. Expression of isoforms p19ARF and p15INK4b is not affected. (J:193498)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  62 strains or lines available
References
Original:  J:193498 Burd CE, et al., Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell. 2013 Jan 17;152(1-2):340-51
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory