Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igs6tm2(ACTB-EGFP,-tdTomato)Luo
Name:	intergenic site 6; targeted mutation 2, Liqun Luo
MGI ID:	MGI:5470397
Synonyms:	Iis6tm2(ACTB-EGFP,-tdTomato)Luo, MADM-12GT
Gene:	Igs6  Location: unknown  Genetic Position: Chr12, 1.71 cM
Alliance:	Igs6tm2(ACTB-EGFP,-tdTomato)Luo page

Germline Transmission:	Earliest citation of germline transmission: J:194079
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The GT MADM targeting construct was designed with a CMV enhancer/chicken beta-actin core promoter (pCA), the N-terminal portion of a mutant enhanced green fluorescent protein (mut4-EGFP; aa 1-273), a beta-globin intronic sequence containing an frt site and loxP-flanked neomycin resistance gene, the C-terminal portion of a red fluorescent protein (tdTomato; aa 4-1544) tagged with three copies of the Myc epitope at its C-terminus, and an SV40 T-antigen poly(A) signal. This entire GT MADM construct was inserted into the Iis6 locus located about 16 kb downstream of exon 1 of the Rab10 gene at 1.71 cM. (J:194079)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igs6 Mutation:	2 strains or lines available

Original:	J:194079 Hippenmeyer S, et al., Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. Cell Rep. 2013 Mar 28;3(3):960-7
All:	1 reference(s)