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Pfn1tm1Foxp
Targeted Allele Detail
Summary
Symbol: Pfn1tm1Foxp
Name: profilin 1; targeted mutation 1, Paul L Fox
MGI ID: MGI:5470084
Synonyms: Pfn1flox:Y129F
Gene: Pfn1  Location: Chr11:70542676-70545470 bp, - strand  Genetic Position: Chr11, 43.21 cM, cytoband A-D
Alliance: Pfn1tm1Foxp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193938
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 3 was floxed. A modified exon 3 with an A to T transversion that results in the amino acid substitution of phenylalanine for tyrsorine at position 129 (Y129F). Cre-mediated recombination is required to remove the wild-type exon 3 and allow for expression of the modified exon 3. (J:193938)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pfn1 Mutation:  10 strains or lines available
References
Original:  J:193938 Fan Y, et al., Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 2012 Oct;14(10):1046-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory