Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Raratm3.1Ipc
Name:	retinoic acid receptor, alpha; targeted mutation 3.1, Pierre Chambon
MGI ID:	MGI:2386107
Synonyms:	RARalpha L-
Gene:	Rara  Location: Chr11:98818644-98865768 bp, + strand  Genetic Position: Chr11, 62.76 cM, cytoband D-E1
Alliance:	Raratm3.1Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:75135
Parent Cell Line:	D4 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed fragment containing exon 8 was excised from Raratm3Ipc by mating with mice carrying Tg(CMV-cre)1Ipc . The deletion eliminated the majority of the DNA binding domain and introduced a frameshift mutation. A lack of protein expression was demonstrated in homozygous mutant mice via immunohistochemical analysis of testis sections. (J:75135)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rara Mutation:	79 strains or lines available

Original:	J:75135 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene. Genesis. 2002 Feb;32(2):87-90
All:	10 reference(s)