Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlr4tm1Djh
Name:	toll-like receptor 4; targeted mutation 1, David J Hackam
MGI ID:	MGI:5469002
Synonyms:	Tlr4loxP
Gene:	Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4tm1Djh page

Germline Transmission:	Earliest citation of germline transmission: J:192520
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The Flp recombinase (flp deleter), which effectively recombined the Frt sites flanking the neo gene, left behind the loxP sites flanking the exon 2. (J:192520, J:193668)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	90 strains or lines available

Original:	J:192520 Sodhi CP, et al., Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology. 2010 Jan;138(1):185-96
All:	25 reference(s)