Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vps35tm1.2Mjff
Name:	VPS35 retromer complex component; targeted mutation 1.2,The Michael J Fox Foundation
MGI ID:	MGI:5466855
Synonyms:	cVKI, VPS35FLOX
Gene:	Vps35  Location: Chr8:85987014-86026146 bp, - strand  Genetic Position: Chr8, 41.61 cM
Alliance:	Vps35tm1.2Mjff page

Germline Transmission:	Earliest citation of germline transmission: J:274797
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeted vector containing a floxed "mini-cDNA" including a splice acceptor and normal cDNA sequence for exons 15-17, followed by a frt-flanked neo cassette and a third loxP site, inserted into intron 14, and a nucleotide change causing a D620N mutation in the inherent mouse gene sequence 3' of the insertion. The polyadenylation signal sequence at the end of the mini-cDNA prevents expression of the D620N mutation. Flp-mediated recombination removed the neo cassette. (J:274797)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vps35 Mutation:	44 strains or lines available

Original:	J:274797 Cataldi S, et al., Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice. NPJ Parkinsons Dis. 2018;4:27
All:	5 reference(s)