Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Sp7tm1.1Rnis Name: Sp7 transcription factor 7; targeted mutation 1.1, Riko Nishimura MGI ID: MGI:5466596 Synonyms: Osterix-deltaflox Gene: Sp7  Location: Chr15:102265038-102275498 bp, - strand  Genetic Position: Chr15, 57.51 cM Alliance: Sp7tm1.1Rnis page

Arrest of endochondral ossification and lack of calcification in Sp7tm1.1Rnis/Sp7tm1.1Rnis mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:191589
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed part of the coding sequence. Immunohistochemistry confirmed the absence of protein expression in the tibia. (J:191589)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp7 Mutation:	21 strains or lines available

Original:	J:191589 Nishimura R, et al., Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem. 2012 Sep 28;287(40):33179-90
All:	2 reference(s)