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Sp7tm1Rnis
Targeted Allele Detail
Nomenclature
Symbol: Sp7tm1Rnis
Name: Sp7 transcription factor 7; targeted mutation 1, Riko Nishimura
MGI ID: MGI:5466595
Synonyms: Osterix-floxed
Gene: Sp7  Location: Chr15:102356603-102367035 bp, - strand  Genetic Position: Chr15, 57.51 cM
Impairment of ossification in various conditional Sp7tm1Rnis/Sp7tm1Rnis mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191589
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of the coding sequence. An additional loxP site was inserted into the coding sequence. (J:191589)
Generation of the Sp7tm1Rnis allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sp7 Mutation:  12 strains or lines available
References
Original:  J:191589 Nishimura R, et al., Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem. 2012 Sep 28;287(40):33179-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/05/2021
MGI 6.16
The Jackson Laboratory