Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Esr1tm4.1Ksk
Name:	estrogen receptor 1 (alpha); targeted mutation 1.1, Kenneth S Korach
MGI ID:	MGI:5465423
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm4.1Ksk page

Germline Transmission:	Earliest citation of germline transmission: J:191182
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette was subsequently removed from properly targeted mice by cre excision leaving exon 3 flanked by loxP sites. (J:191182)

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:191182 Hewitt SC, et al., Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J. 2010 Dec;24(12):4660-7
All:	23 reference(s)