Ngftm1.1Blhe
Targeted Allele Detail
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| Symbol: |
Ngftm1.1Blhe |
| Name: |
nerve growth factor; targeted mutation 1.1, Barbara L Hempstead |
| MGI ID: |
MGI:5461488 |
| Synonyms: |
proNgf-HA |
| Gene: |
Ngf Location: Chr3:102377235-102428329 bp, + strand Genetic Position: Chr3, 45.25 cM
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| Alliance: |
Ngftm1.1Blhe page
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Adult Ngftm1.1Blhe/Ngf+ mice exhibit dilated cardiomyopathy and fibrosis and this phentoype is rescued in Ngfrtm1Jae/Ngfrtm1Jae Ngftm1.1Blhe/Ngf+ mice
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:190893
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Nucleotide substitutions result in the amino acid substitution of lysine and arginine for two alanines at positions 120 and 121 within the furin recognition site. Cre-mediated recombination removed the FRT- and loxP-flanked neo cassette inserted upstream of the modified exon. An HA-tag was inserted in-frame before the stop codon.
(J:190893)
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Generation of the Ngftm1.1Blhe allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ngf Mutation: |
12 strains or lines available
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| Original: |
J:190893 Siao CJ, et al., ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. J Exp Med. 2012 Nov 19;209(12):2291-305 |
| All: |
1 reference(s) |
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Analysis Tools
