Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adcy3tm1.1Hazh
Name:	adenylate cyclase 3; targeted mutation 1.1, Haiqing Zhao
MGI ID:	MGI:5461479
Synonyms:	ACIIIS1076A
Gene:	Adcy3  Location: Chr12:4183397-4263525 bp, + strand  Genetic Position: Chr12, 1.99 cM, cytoband A-B
Alliance:	Adcy3tm1.1Hazh page

Germline Transmission:	Earliest citation of germline transmission: J:190988
Parent Cell Line:	MC1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Single point mutation   Mutation details: Exon 21 was replaced with a modified one in which a T to G transition results in the amino acid substitution of alanine for serine at position 1076 (S1076A). A self-excising neo cassette inserted downstream of the modified exon was removed. (J:190988)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcy3 Mutation:	42 strains or lines available

Original:	J:190988 Cygnar KD, et al., Phosphorylation of adenylyl cyclase III at serine1076 does not attenuate olfactory response in mice. J Neurosci. 2012 Oct 17;32(42):14557-62
All:	1 reference(s)