Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Nr2f2tm1Tsa
Name:	nuclear receptor subfamily 2, group F, member 2; targeted mutation 1, Sophia Y Tsai
MGI ID:	MGI:2385933
Synonyms:	COUP-TFII (-)
Gene:	Nr2f2  Location: Chr7:70001692-70016483 bp, - strand  Genetic Position: Chr7, 38.66 cM
Alliance:	Nr2f2tm1Tsa page

Germline Transmission:	Earliest citation of germline transmission: J:54469
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding most the amino terminus, all of the DNA binding domain, and a portion of the ligand binding domain was replaced with a neomycin selection cassette. The absence of transcript was determined by RT-PCR analysis and in situ hybridization of homozygous mutant embryos. (J:54469)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr2f2 Mutation:	27 strains or lines available

Original:	J:54469 Pereira FA, et al., The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 1999 Apr 15;13(8):1037-49
All:	9 reference(s)