Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hprt1tm1(CMV-GFP)Nat
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:5449926
Synonyms:	CAG-LSL-nlsGFP, Hprttm1(CMV-LSL-nlsGFP)Nat
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm1(CMV-GFP)Nat page

Germline Transmission:	Earliest citation of germline transmission: J:220411
Parent Cell Line:	mEMS1204 (ES Cell)
Strain of Origin:	(B6.129P2-Hprt1b-m3/J x 129S-Gt(ROSA)26Sortm1Sor/J)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A pair of insulator sequences, CMV enhancer/beta-actin promoter, loxP site, 3 stop transcription sites, loxP site, nuclear localized (nls) GFP-6xMyc epitope, rabbit beta-globin 3' UTR, and a pair of insulator sequences were inserted into the gene in the indicated order via targeted recombination. (J:220411)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1273 strains or lines available

Original:	J:220411 Wu H, et al., Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease. Neuron. 2014 Jan 8;81(1):103-19
All:	2 reference(s)