Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Neurog3-cre/ERT2)1Able
Name:	transgene insertion 1, Andrew B Leiter
MGI ID:	MGI:5449724
Synonyms:	Ngn3-Cre/ERT2
Transgene:	Tg(Neurog3-cre/ERT2)1Able  Location: unknown
Alliance:	Tg(Neurog3-cre/ERT2)1Able page

Strain of Origin:

C57BL/6 x (C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Neurog3-cre/ERT2)1Able expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Neurog3   Mutation details: Homologous recombination inserted the cre recombinase sequence fused to a mutated tamoxifen-inducible estrogen receptor (cre/ERT2) into the translation initiation ATG codon of the neurogenin 3 gene located in a BAC. Three founder lines were obtained which all produced nearly identical patterns of cre expression. A generic line 1 was created as representative. (J:190530)

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (species not specified) Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:190530 Li HJ, et al., Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012 Nov 15;371(2):156-69
All:	3 reference(s)