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Gt(ROSA)26Sortm2.1(CAG-hop/EYFP)Imayo
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2.1(CAG-hop/EYFP)Imayo
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Itaru Imayoshi
MGI ID: MGI:5449183
Synonyms: Gt(ROSA)26Sortm1.1(CAG-eNpHR2/EYFP)Imayo, R26-CAG-LoxP-eNpHR2-EYFP
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2.1(CAG-hop/EYFP)Imayo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190172
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsFlp-mediated recombination removed the FRT-flanked stop cassette. The floxed stop cassette remains intact and must be removed to achieve expression of the halorhodopsin from the halophilic bacterium Natronomas pharaonis modified with an N-terminal signal peptide and a C-terminal endoplasmic reticulum export sequence fused in-frame with an enhanced yellow fluorescent protein (eNpHR2-EYFP) under the control of the CAG promoter. (J:190172)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:190172 Imayoshi I, et al., Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0. Neurosci Res. 2013 Jan;75(1):53-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory