Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Atp7atm1.1Mjp Name: ATPase, Cu++ transporting, alpha polypeptide; targeted mutation 1.1, Michael J Petris MGI ID: MGI:5447640 Synonyms: Atp7afl Gene: Atp7a  Location: ChrX:105070882-105168532 bp, + strand  Genetic Position: ChrX, 47.36 cM Alliance: Atp7atm1.1Mjp page

Patches of hypopigmentation in coats of Atp7atm1.1Mjp/Atp7a+ Cldn6tm1(cre)Dkwu/Cldn6+ females Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:189931
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:189931)

Generation of the Atp7atm1.1Mjp allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp7a Mutation:	69 strains or lines available

Original:	J:189931 Wang Y, et al., Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis. PLoS One. 2012;7(8):e43039
All:	6 reference(s)