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Myctm1.1(MYC)Gwbk
Targeted Allele Detail
Summary
Symbol: Myctm1.1(MYC)Gwbk
Name: myelocytomatosis oncogene; targeted mutation 1.1, Georg W Bornkamm
MGI ID: MGI:5447463
Synonyms: hc-Myc
Gene: Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance: Myctm1.1(MYC)Gwbk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189677
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence between the first translation start site (CUG) in exon 1 and the translation termination site (TAA) in exon 3 was replaced with the corresponding human sequence. Flp-mediated recombination removed a floxed neo cassette inserted into intron 2. The insertion produces a humanized Myc. (J:189677)
Generation of the Myctm1.1(MYC)Gwbk allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myc Mutation:  42 strains or lines available
Notes
Humanized Myc
References
Original:  J:189677 Lehmann FM, et al., Humanized c-Myc mouse. PLoS One. 2012;7(7):e42021
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory