Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Neurod2-Smo*A2)#Jols
Name:	transgene insertion, James M Olson
MGI ID:	MGI:5447065
Synonyms:	ND2:SmoA2
Transgene:	Tg(Neurod2-Smo*A2)#Jols  Location: unknown
Alliance:	Tg(Neurod2-Smo*A2)#Jols page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence) Mutation:    Insertion   Tg(Neurod2-Smo*A2)#Jols expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Smo (MGI:108075)   Mutation details: The ND2:SmoA2 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA2 (S537N), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Four lines were generated (221, 222, 225 and 242). All lines exhibit a low level of transgene expression (4-, 1-, 3- and 2-fold, respectively for each line relative to wild-type levels). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:93861)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:93861 Hallahan AR, et al., The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004 Nov 1;64(21):7794-800
All:	4 reference(s)