Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mdm2tm2.1Snj
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 2.1, Steven N Jones
MGI ID:	MGI:5446921
Synonyms:	Mdm2A, Mdm2S394A
Gene:	Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2tm2.1Snj page

Germline Transmission:	Earliest citation of germline transmission: J:189297
Parent Cell Line:	PC3 (ES Cell)
Strain of Origin:	129S4/SvJae-Tg(Prm-cre)70Og

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Serine codon 394 (TCC) was changed to alanine (GCC) (p.S394A). Cre-mediated recombination removed the loxP site flanked neomycin resistance gene cassette that was inserted downstream of exon 12. (J:189297)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Mdm2tm2.1Snj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

Original:	J:189297 Gannon HS, et al., ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell. 2012 May 15;21(5):668-79
All:	3 reference(s)