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Zfhx3tm1.2Jtd
Targeted Allele Detail
Summary
Symbol: Zfhx3tm1.2Jtd
Name: zinc finger homeobox 3; targeted mutation 1.2, Jin-Tang Dong
MGI ID: MGI:5446506
Synonyms: Atbf1delta7and8
Gene: Zfhx3  Location: Chr8:109005975-109688268 bp, + strand  Genetic Position: Chr8, 56.02 cM, cytoband E1
Alliance: Zfhx3tm1.2Jtd page
Reduced body size of Zfhx3tm1.2Jtd/Zfhx3+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189563
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the neo cassette, exon 7 and exon 8. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts following treatment with a cre-expressing adenovirus. (J:189563)
Generation of the Zfhx3tm1.2Jtd allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfhx3 Mutation:  130 strains or lines available
References
Original:  J:189563 Sun X, et al., Heterozygous deletion of Atbf1 by the Cre-loxP system in mice causes preweaning mortality. Genesis. 2012 Nov;50(11):819-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory