Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myctm1.1Itl
Name:	myelocytomatosis oncogene; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID:	MGI:5444112
Synonyms:	Myc 3' WRE-
Gene:	Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance:	Myctm1.1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:188927
Parent Cell Line:	iTL BA1 (ES Cell)
Strain of Origin:	(C57BL/6NTac x 129S6/SvEvTac)F1

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette replaced the 3' Wnt responsive DNA element (WRE). Flp-mediated recombination removed the neo cassette. RT-PCR confirmed increased transcript expression in the colon. (J:188927)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:	42 strains or lines available

Original:	J:188927 Konsavage WM Jr, et al., The Myc 3' Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol. 2012 Oct;32(19):3891-902
All:	2 reference(s)