Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Jundtm1Mya
Name:	jun D proto-oncogene; targeted mutation 1, Moshe Yaniv
MGI ID:	MGI:2385829
Synonyms:	JunD-, Jundtm1Wag
Gene:	Jund  Location: Chr8:71151599-71153265 bp, + strand  Genetic Position: Chr8, 34.15 cM, cytoband C2
Alliance:	Jundtm1Mya page

Germline Transmission:	Earliest citation of germline transmission: J:53906
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire gene was replaced with an in-frame lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of various tissues from homozygous mutant animals. Western blot of mouse embryonic fibroblasts derived from homozygous mutants did not detect protein product. LacZ expression was observed in mutant embryos via X-gal staining. (J:53906)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jund Mutation:	3 strains or lines available

Original:	J:53906 Thepot D, et al., Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. Development. 2000 Jan;127(1):143-53
All:	22 reference(s)