About   Help   FAQ
Fosl1tm1Wag
Targeted Allele Detail
Summary
Symbol: Fosl1tm1Wag
Name: fos-like antigen 1; targeted mutation 1, Erwin F Wagner
MGI ID: MGI:2385824
Synonyms: Fra1-
Gene: Fosl1  Location: Chr19:5497726-5505966 bp, + strand  Genetic Position: Chr19, 4.33 cM
Alliance: Fosl1tm1Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65292
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 3, all of intron 3, and part of exon 4 were replaced with a lacZ-neo derived cassette via homologous recombination, fusing lacZ in-frame with exon 3. The gene targeting event deletes most of the DNA-binding domain, the leucine zipper dimerization domain, and the last splice acceptor site. Homozygous mutant embryos were detected up to E11.5 by Southern blot analysis. (J:65292)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fosl1 Mutation:  16 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+). Mutant animals derived from each cell line were analysed. Survival of homozygous embryos rescued when ES cells are injected into wild-type tetraploid blastocysts. - - J:65292
References
Original:  J:65292 Schreiber M, et al., Placental vascularisation requires the AP-1 component fra1. Development. 2000 Nov;127(22):4937-48
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory