Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Shhtm1Ahk
Name:	sonic hedgehog; targeted mutation 1, Andreas H Kottmann
MGI ID:	MGI:5440762
Synonyms:	ShhlacZ, Shh-nLZC
Gene:	Shh  Location: Chr5:28661838-28672099 bp, - strand  Genetic Position: Chr5, 14.39 cM
Alliance:	Shhtm1Ahk page

Germline Transmission:	Earliest citation of germline transmission: J:188348
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2. A reporter construct (IRES, lacZ, polyadenylation sequence and floxed neo cassette) was inserted into the 3' untranslated region of exon 3. (J:188348)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shh Mutation:	45 strains or lines available

Original:	J:188348 Gonzalez-Reyes LE, et al., Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron. 2012 Jul 26;75(2):306-19
All:	8 reference(s)