Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Mapttm1.1Cole
Name:	microtubule-associated protein tau; targeted mutation 1.1, Michael Coleman
MGI ID:	MGI:5440079
Synonyms:	tauP301L
Gene:	Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapttm1.1Cole page

Germline Transmission:	Earliest citation of germline transmission: J:188213
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6JOlaHsd

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Single point mutation   Mutation details: Exon 10 was replaced with a floxed neo cassette and a modified exon 10 in which a C to T transition results in the amino acid substitution of leucine for proline at position 301 (P301L). Cre-mediated recombination removed the neo cassette. (J:188213)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:	428 strains or lines available

Original:	J:188213 Gilley J, et al., Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse. Neurobiol Aging. 2012 Mar;33(3):621.e1-621.e15
All:	4 reference(s)