Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Htr1atm3.1Rhn
Name:	5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 3.1, Rene Hen
MGI ID:	MGI:5439287
Synonyms:	Htr1atetO, Htr1A tetO
Gene:	Htr1a  Location: Chr13:105580147-105584630 bp, + strand  Genetic Position: Chr13, 56.92 cM
Alliance:	Htr1atm3.1Rhn page

Germline Transmission:	Earliest citation of germline transmission: J:137439
Parent Cell Line:	CSL3 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Flexible Accelerated STOP Tetracycline Operator (tetO)-knockin (FAST) was used to insert a construct containing a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO) and loxP site was inserted upstream of the translation initiation site. Flp-mediated recombination removed the neo/STOP cassette and left the tetO floxed and intact. Autoradiography confirmed a 20% reduction in protein expression. (J:137439, J:167659)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr1a Mutation:	26 strains or lines available

Original:	J:137439 Audero E, et al., Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science. 2008 Jul 4;321(5885):130-3
All:	9 reference(s)