Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dag1tm1.1Swin
Name:	dystroglycan 1; targeted mutation 1.1, Steve J Winder
MGI ID:	MGI:5438989
Synonyms:	Dag1Y890F
Gene:	Dag1  Location: Chr9:108082060-108141176 bp, - strand  Genetic Position: Chr9, 59.08 cM
Alliance:	Dag1tm1.1Swin page

Germline Transmission:	Earliest citation of germline transmission: J:187750
Parent Cell Line:	PC3 (ES Cell)
Strain of Origin:	129S4/SvJae-Tg(Prm-cre)70Og

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Single point mutation   Mutation details: A loxP site flanked neomycin resistance gene cassette was inserted upstream of exon 2. Exon 2 was replaced with a modified version in which a nucleotide substitution (A to T) results in the amino acid substitution of tyrosine with phenylalanine at position 890 (Y890F). Subsequent cre-mediated recombination removed the neo cassette. (J:187750)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dag1 Mutation:	109 strains or lines available

Original:	J:187750 Miller G, et al., Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse. Hum Mol Genet. 2012 Oct 15;21(20):4508-20
All:	1 reference(s)