Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Bernhard G Herrmann
MGI ID:	MGI:5438577
Synonyms:	Ctnnb1mut, tet:tg-dTomato_TA_Ctnnb1mut
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh page

Germline Transmission:	Earliest citation of germline transmission: J:187862
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(C57BL/6 x 129S6/SvEvTac)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Ctnnb1 (MGI:88276)   Mutation details: Recombinase-mediated cassette exchange (RMCE) introduced into the locus a construct containing a tetracycline-responsive element that drives inducible expression of a tdTomato and mutated mouse cDNA (S33A, S37A, T41A, S45A) separated by a self-cleaving TA peptide. (J:187862)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:187862 Farrall AL, et al., Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer. 2012 Nov 15;131(10):2242-52
All:	1 reference(s)