Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Brca2tm1.1Sks
Name:	breast cancer 2, early onset; targeted mutation 1.1, Shyam K Sharan
MGI ID:	MGI:5438023
Synonyms:	Brca2F2351D
Gene:	Brca2  Location: Chr5:150446095-150493794 bp, + strand  Genetic Position: Chr5, 89.52 cM
Alliance:	Brca2tm1.1Sks page

Germline Transmission:	Earliest citation of germline transmission: J:187434
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Nucleotide substitutions (TTC to GAC) result in the amino acid substitution of aspartic acid for phenylalanine at position 2351 (F2351D). A floxed neo cassette inserted in intron 14 was removed by cre-mediated recombination. (J:187434)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:	132 strains or lines available

Original:	J:187434 Biswas K, et al., Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet. 2012 Sep 15;21(18):3993-4006
All:	1 reference(s)