Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Calcatm1.1(EGFP/HBEGF)Mjz
Name:	calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1.1, Mark Zylka
MGI ID:	MGI:5437493
Synonyms:	CGRPalpha-GFP
Gene:	Calca  Location: Chr7:114230713-114235592 bp, - strand  Genetic Position: Chr7, 59.99 cM
Alliance:	Calcatm1.1(EGFP/HBEGF)Mjz page

Germline Transmission:	Earliest citation of germline transmission: J:187267
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/Sv

Allele Type:    Targeted (Inserted expressed sequence, Reporter) Mutation:    Insertion   Calcatm1.1(EGFP/HBEGF)Mjz expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human HBEGF (1839) Hbegf  (MGI:96070)   Mutation details: An FRT-flanked neo cassette, floxed farnesylated EGFP and human diphtheria toxin receptor (HBEGF/DTR) were inserted at the translation initiation site. Flp-mediated recombination removed the neo cassette and allowed for the expression of the GFP and HBEGF. (J:187267)

Schematic of the Calcatm1.1(EGFP/HBEGF)Mjz allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Calca Mutation:	21 strains or lines available

Original:	J:187267 McCoy ES, et al., CGRPalpha-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch. PLoS One. 2012;7(5):e36355
All:	17 reference(s)