Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Esr1tm1Gust
Name:	estrogen receptor 1 (alpha); targeted mutation 1, Jan-Ake Gustafsson
MGI ID:	MGI:5433575
Synonyms:	ERalphaflox
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm1Gust page

Germline Transmission:	Earliest citation of germline transmission: J:186230
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:186230)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:186230 Antonson P, et al., Generation of ERalpha-floxed and knockout mice using the Cre/LoxP system. Biochem Biophys Res Commun. 2012 Aug 10;424(4):710-6
All:	10 reference(s)