Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hey2tm2.1Mtc
Name:	hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 2.1, Michael T Chin
MGI ID:	MGI:5433499
Synonyms:	CHF1Flox
Gene:	Hey2  Location: Chr10:30708355-30718779 bp, - strand  Genetic Position: Chr10, 17.19 cM, cytoband A4
Alliance:	Hey2tm2.1Mtc page

Germline Transmission:	Earliest citation of germline transmission: J:186570
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:186570)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hey2 Mutation:	30 strains or lines available

Original:	J:186570 Liu Y, et al., Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1860-70
All:	2 reference(s)