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Apptm1Yah
Targeted Allele Detail
Summary
Symbol: Apptm1Yah
Name: amyloid beta precursor protein; targeted mutation 1, Yann Herault
MGI ID: MGI:5431210
Gene: App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance: Apptm1Yah page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185269
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsA MICER vector was used to insert a puromycin resistance cassette, a loxP site and the 3' half of an Hprt minigene between exons 16 and 17 of the amyloid precursor protein (App) gene in ES cells already bearing Runx1tm1Yg, which contains a loxP-flanked neomycin resistance cassette upstream of exon 2 of the runt related transcription factor 1 (Runx1) gene. Apptm1Yah resulted from the vector's integration into the same copy of Chr 16, i.e., in cis with Runx1tm1Yg. All loxP sites are directed distally on the chromosome. (J:185269)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  88 strains or lines available
Notes
This allele is encountered only in cis with Runx1tm1Yg.
References
Original:  J:185269 Raveau M, et al., The app-runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a down syndrome mouse model. PLoS Genet. 2012 May;8(5):e1002724
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory