Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ctnnb1tm1.2Wvv
Name:	catenin beta 1; targeted mutation 1.2, Wendy van Veelen
MGI ID:	MGI:5430598
Synonyms:	beta-cateninE654
Gene:	Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance:	Ctnnb1tm1.2Wvv page

Germline Transmission:	Earliest citation of germline transmission: J:185942
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 12 and a floxed FRT flanked PGK-neomycin selection cassette was inserted downstream of exon 15 followed by a duplication of exons 12-15. A tyrosine to glutamic acid codon change was incorporated at codon 654 of the duplicated exon 13. Correctly targeted mice were bred to "CAG-flp" mice to remove the selection cassette. Subsequent mating to "CAG-cre" mice substituted the mutated copy of exons 12-15 for the unmodified copy. (J:185942)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:	49 strains or lines available

Original:	J:185942 van Veelen W, et al., beta-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis. Gut. 2011 Sep;60(9):1204-12
All:	2 reference(s)