Col1a1<tm2(tetO-Yap1)Lrsn> Targeted Allele Detail MGI Mouse (MGI:5430524)

Col1a1^{tm2(tetO-Yap1)Lrsn}
Targeted Allele Detail

Summary

Symbol:	Col1a1^{tm2(tetO-Yap1)Lrsn}
Name:	collagen, type I, alpha 1; targeted mutation 2, Nils-Goran Larsson
MGI ID:	MGI:5430524
Synonyms:	tet-YAP
Gene:	Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D

Mutation
origin

Mutation
description

Allele Type:		Targeted (Inducible, Inserted expressed sequence, RMCE-ready)
Inducer:		doxycycline/tetracycline
Mutation:		Insertion
		Mutation details: RMCE on KH2 cells inserted a cassette into the 3' UTR. The cassette contains the tetracycline responsive element (tetO) driving inducible expression of Yap1). (J:185310)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Notes

The allele was made in KH2 cells that carry Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} and Col1a1^{tm13(neo/hygro*)Jae} (J:159351). This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

Original:	J:185310 Jansson L, et al., Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1. PLoS One. 2012;7(2):e32013
All:	2 reference(s)

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