Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO-Yap1*)Lrsn
Name:	collagen, type I, alpha 1; targeted mutation 1, Nils-Goran Larsson
MGI ID:	MGI:5430522
Synonyms:	tet-YAPmut
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO-Yap1*)Lrsn page

Germline Transmission:	Earliest citation of germline transmission: J:185310
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Constitutively active, Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-Yap1*)Lrsn expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Yap1 (MGI:103262)   Mutation details: RMCE on KH2 cells, which contain Gt(ROSA)26Sortm1(rtTA*M2)Jae and a FRT-flanked PGK-Neo-pA in the 3' UTR of Col1a1, replaced the FRT-flanked neo cassette with a cassette that contained the tetracycline response element driving inducible expression of the mouse cDNA with nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 127 (S127A). This mutation results in a constitutively active protein. (J:185310)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:185310 Jansson L, et al., Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1. PLoS One. 2012;7(2):e32013
All:	5 reference(s)