Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hprt1tm1(Nphs1-CMIP)Dsah
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Djillali Sahali
MGI ID:	MGI:5428689
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm1(Nphs1-CMIP)Dsah page

Germline Transmission:	Earliest citation of germline transmission: J:185411
Parent Cell Line:	BPES (ES Cell)
Strain of Origin:	(129-Hprt1b-m3 x C57BL/6)F1

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Hprt1tm1(Nphs1-CMIP)Dsah expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human CMIP (80790) Cmip  (MGI:1921690)   Mutation details: A transgene containing the mouse promoter driving podocyte-specifc expression of the human cDNA with a human HPRT sequence for selection was targeted to the locus. (J:185411)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1273 strains or lines available

Original:	J:185411 Zhang SY, et al., c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci Signal. 2010;3(122):ra39
All:	1 reference(s)