Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hprt1tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Genoway
MGI ID:	MGI:5428335
Synonyms:	PLB1
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno page

Germline Transmission:	Earliest citation of germline transmission: J:180977
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Hprt1tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno expresses 2 genes Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human APP (351) App  (MGI:88059) human MAPT (4137) Mapt  (MGI:97180)   Mutation details: A construct containing the Camk2a promoter, loxP site, human APP cDNA with the Sweden and London mutations (K670N, M671L and V717I), FRT site, IRES, loxP site, human MAPT cDNA with P301L and R406W mutations, FRT site and neo cassette was inserted into the locus. (J:180977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1273 strains or lines available

Original:	J:180977 Platt B, et al., Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PLoS One. 2011;6(11):e27068
All:	2 reference(s)