Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Gata4tm1Grg Name: GATA binding protein 4; targeted mutation 1, Vidu Garg MGI ID: MGI:5427934 Synonyms: Gata4 G295Ski Gene: Gata4  Location: Chr14:63436371-63509141 bp, - strand  Genetic Position: Chr14, 33.24 cM Alliance: Gata4tm1Grg page

Growth retardation and a thin myocardium in Gata4tm1Grg/Gata4tm1Grg mice Show the 9 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:185124
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Humanized sequence, Hypomorph) Mutations:    Insertion, Single point mutation   Mutation details: A G to A mutation was introduced in exon 3 creating a glycine to serine substitution (G295S) and a floxed neo cassette was inserted downstream of exon 4 via homologous recombination. Immunoblot analysis indicated that protein levels in homozygous mice are similar to wild-type. (J:185124)

Targeting strategy for generation of Gata4tm1Grg knock-in allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:	36 strains or lines available

Original:	J:185124 Misra C, et al., Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012 May;8(5):e1002690
All:	2 reference(s)