Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3c3tm1.1Flv
Name:	phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1.1, Richard A Flavell
MGI ID:	MGI:5427838
Synonyms:	Pik3c3flox
Gene:	Pik3c3  Location: Chr18:30405800-30481179 bp, + strand  Genetic Position: Chr18, 17.41 cM
Alliance:	Pik3c3tm1.1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:184753
Parent Cell Line:	JM8 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:184753)

Generation of the Pik3c3tm1.1Flv allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3c3 Mutation:	45 strains or lines available

Original:	J:184753 Willinger T, et al., Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8670-5
All:	4 reference(s)